Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

Human islet amyloid polypeptide (hIAPP) is the major component of the amyloid deposits found in the pancreatic islets of patients with type 2 diabetes mellitus (T2DM). Mature hIAPP, a 37-aa peptide, is natively unfolded in its monomeric state but forms islet amyloid in T2DM. In common with other mis...

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Detalles Bibliográficos
Autores principales: Caillon, Lucie, Hoffmann, Anais R. F., Botz, Alexandra, Khemtemourian, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655289/
https://www.ncbi.nlm.nih.gov/pubmed/26636105
http://dx.doi.org/10.1155/2016/5639875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655289/
https://www.ncbi.nlm.nih.gov/pubmed/26636105
http://dx.doi.org/10.1155/2016/5639875

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