Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis

Human carbamoyl phosphate synthetase (CPS1), a 1500-residue multidomain enzyme, catalyzes the first step of ammonia detoxification to urea requiring N-acetyl-L-glutamate (NAG) as essential activator to prevent ammonia/amino acids depletion. Here we present the crystal structures of CPS1 in the absen...

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Detalles Bibliográficos
Autores principales: de Cima, Sergio, Polo, Luis M., Díez-Fernández, Carmen, Martínez, Ana I., Cervera, Javier, Fita, Ignacio, Rubio, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655335/
https://www.ncbi.nlm.nih.gov/pubmed/26592762
http://dx.doi.org/10.1038/srep16950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655335/
https://www.ncbi.nlm.nih.gov/pubmed/26592762
http://dx.doi.org/10.1038/srep16950

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