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Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis

Human carbamoyl phosphate synthetase (CPS1), a 1500-residue multidomain enzyme, catalyzes the first step of ammonia detoxification to urea requiring N-acetyl-L-glutamate (NAG) as essential activator to prevent ammonia/amino acids depletion. Here we present the crystal structures of CPS1 in the absen...

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Detalles Bibliográficos
Autores principales:	de Cima, Sergio, Polo, Luis M., Díez-Fernández, Carmen, Martínez, Ana I., Cervera, Javier, Fita, Ignacio, Rubio, Vicente
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655335/ https://www.ncbi.nlm.nih.gov/pubmed/26592762 http://dx.doi.org/10.1038/srep16950

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