Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs). In this study, we identified the operative molecular mechanisms through which dynamic tensile loading (DL) regulates changes in chromatin organization and nuclear mechanics in MSCs. Our data show that, in the absence of...

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Detalles Bibliográficos
Autores principales: Heo, Su-Jin, Thorpe, Stephen D., Driscoll, Tristan P., Duncan, Randall L., Lee, David A., Mauck, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655352/
https://www.ncbi.nlm.nih.gov/pubmed/26592929
http://dx.doi.org/10.1038/srep16895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655352/
https://www.ncbi.nlm.nih.gov/pubmed/26592929
http://dx.doi.org/10.1038/srep16895

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