Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase

Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen responsible for many human infections. LasI is an acyl-homoserine lactone synthase that produces a quorum-sensing (QS) signal that positively regulates numerous P. aeruginosa virulence determinants. The inhibition of the LasI protein...

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Detalles Bibliográficos
Autores principales: Lidor, O., Al-Quntar, A., Pesci, E. C., Steinberg, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655403/
https://www.ncbi.nlm.nih.gov/pubmed/26593271
http://dx.doi.org/10.1038/srep16569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655403/
https://www.ncbi.nlm.nih.gov/pubmed/26593271
http://dx.doi.org/10.1038/srep16569

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