Efficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1

Clustered DNA damage is a unique characteristic of radiation-induced DNA damage and the formation of these sites poses a serious challenge to the cell’s repair machinery. Within a cell DNA is compacted, with nucleosomes being the first order of higher level structure. However, few data are reported...

Descripción completa

Detalles Bibliográficos
Autores principales: Eccles, Laura J., Menoni, Hervé, Angelov, Dimitar, Lomax, Martine E., O’Neill, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655832/
https://www.ncbi.nlm.nih.gov/pubmed/26439176
http://dx.doi.org/10.1016/j.dnarep.2015.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655832/
https://www.ncbi.nlm.nih.gov/pubmed/26439176
http://dx.doi.org/10.1016/j.dnarep.2015.08.003

Ejemplares similares