Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

Cyclin-dependent kinase 12 (CDK12) promotes transcriptional elongation by phosphorylation of the RNA polymerase II C-terminal domain (CTD). Structure-function studies show that this activity is dependent on a C-terminal kinase extension, as well as the binding of cyclin K (CycK). To better define th...

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Detalles Bibliográficos
Autores principales: Dixon-Clarke, Sarah E., Elkins, Jonathan M., Cheng, S.-W. Grace, Morin, Gregg B., Bullock, Alex N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656997/
https://www.ncbi.nlm.nih.gov/pubmed/26597175
http://dx.doi.org/10.1038/srep17122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656997/
https://www.ncbi.nlm.nih.gov/pubmed/26597175
http://dx.doi.org/10.1038/srep17122

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