Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

The metabolism of the nonessential amino acid proline contributes to tumor metabolic reprogramming. Previously we showed that MYC increases proline biosynthesis (PB) from glutamine. Here we show MYC increases the expression of the enzymes in PB at both protein and mRNA levels. Blockade of PB decreas...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Hancock, Chad N., Fischer, Joseph W., Harman, Meredith, Phang, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657043/
https://www.ncbi.nlm.nih.gov/pubmed/26598224
http://dx.doi.org/10.1038/srep17206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657043/
https://www.ncbi.nlm.nih.gov/pubmed/26598224
http://dx.doi.org/10.1038/srep17206

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