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Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides
The metabolism of the nonessential amino acid proline contributes to tumor metabolic reprogramming. Previously we showed that MYC increases proline biosynthesis (PB) from glutamine. Here we show MYC increases the expression of the enzymes in PB at both protein and mRNA levels. Blockade of PB decreas...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657043/ https://www.ncbi.nlm.nih.gov/pubmed/26598224 http://dx.doi.org/10.1038/srep17206 |