Oxidative stress–dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration

Oxidative stress is a well-known inducer of neuronal apoptosis and axonal degeneration. We previously showed that the E3 ubiquitin ligase ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B activation. We now demonstrate that oxidative stress serves as an activator of the ubiquiti...

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Detalles Bibliográficos
Autores principales: Wakatsuki, Shuji, Furuno, Akiko, Ohshima, Makiko, Araki, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657170/
https://www.ncbi.nlm.nih.gov/pubmed/26572622
http://dx.doi.org/10.1083/jcb.201506102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657170/
https://www.ncbi.nlm.nih.gov/pubmed/26572622
http://dx.doi.org/10.1083/jcb.201506102

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