Rac1 augments Wnt signaling by stimulating β-catenin–lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import

β-Catenin transduces the Wnt signaling pathway and its nuclear accumulation leads to gene transactivation and cancer. Rac1 GTPase is known to stimulate β-catenin-dependent transcription of Wnt target genes and we confirmed this activity. Here we tested the recent hypothesis that Rac1 augments Wnt si...

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Detalles Bibliográficos
Autores principales: Jamieson, Cara, Lui, Christina, Brocardo, Mariana G., Martino-Echarri, Estefania, Henderson, Beric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657330/
https://www.ncbi.nlm.nih.gov/pubmed/26403202
http://dx.doi.org/10.1242/jcs.167742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657330/
https://www.ncbi.nlm.nih.gov/pubmed/26403202
http://dx.doi.org/10.1242/jcs.167742

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