Cargando…
Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial
As a molecular chaperone and activator of Toll-like receptor 2-mediated protective responses by microglia and macrophages, the small heat shock protein alpha B-crystallin (HspB5) exerts therapeutic effects in different animal models for neuroinflammation, including the model for multiple sclerosis (...
Autores principales: | van Noort, Johannes M., Bsibsi, Malika, Nacken, Peter J., Verbeek, Richard, Venneker, Edna H.G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657879/ https://www.ncbi.nlm.nih.gov/pubmed/26599332 http://dx.doi.org/10.1371/journal.pone.0143366 |
Ejemplares similares
-
HspB5 Activates a Neuroprotective Glial Cell Response in Experimental Tauopathy
por: Hampton, David W., et al.
Publicado: (2020) -
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis
por: Thomas, Olivia G., et al.
Publicado: (2023) -
Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability
por: Berry, James D., et al.
Publicado: (2017) -
Crystallin genes: lens specificity of the murine alpha A-crystallin gene.
por: Chepelinsky, A B, et al.
Publicado: (1987) -
Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis
por: Erni, Silvia T., et al.
Publicado: (2019)