Metformin Radiosensitizes p53-Deficient Colorectal Cancer Cells through Induction of G2/M Arrest and Inhibition of DNA Repair Proteins

The present study addressed whether the combination of metformin and ionizing radiation (IR) would show enhanced antitumor effects in radioresistant p53-deficient colorectal cancer cells, focusing on repair pathways for IR-induced DNA damage. Metformin caused a higher reduction in clonogenic surviva...

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Detalles Bibliográficos
Autores principales: Jeong, Youn Kyoung, Kim, Mi-Sook, Lee, Ji Young, Kim, Eun Ho, Ha, Hunjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657889/
https://www.ncbi.nlm.nih.gov/pubmed/26599019
http://dx.doi.org/10.1371/journal.pone.0143596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657889/
https://www.ncbi.nlm.nih.gov/pubmed/26599019
http://dx.doi.org/10.1371/journal.pone.0143596

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