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Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action
A group of styrylquinolines were synthesized and tested for their anti-proliferative activity. Anti-proliferative activity was evaluated against the human colon carcinoma cell lines that had a normal expression of the p53 protein (HCT116 p53(+/+)) and mutants with a disabled TP53 gene (HCT116 p53(-/...
Autores principales: | Mrozek-Wilczkiewicz, Anna, Spaczynska, Ewelina, Malarz, Katarzyna, Cieslik, Wioleta, Rams-Baron, Marzena, Kryštof, Vladimír, Musiol, Robert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657899/ https://www.ncbi.nlm.nih.gov/pubmed/26599982 http://dx.doi.org/10.1371/journal.pone.0142678 |
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