Non-Darwinian dynamics in therapy-induced cancer drug resistance

Development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces meta-stable phenotypic variants (persisters), some of whi...

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Detalles Bibliográficos
Autores principales: Pisco, Angela Oliveira, Brock, Amy, Zhou, Joseph, Moor, Andreas, Mojtahedi, Mitra, Jackson, Dean, Huang, Sui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657953/
https://www.ncbi.nlm.nih.gov/pubmed/24045430
http://dx.doi.org/10.1038/ncomms3467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657953/
https://www.ncbi.nlm.nih.gov/pubmed/24045430
http://dx.doi.org/10.1038/ncomms3467

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