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A Jump-from-Cavity Pyrophosphate Ion Release Assisted by a Key Lysine Residue in T7 RNA Polymerase Transcription Elongation
Pyrophosphate ion (PPi) release during transcription elongation is a signature step in each nucleotide addition cycle. The kinetics and energetics of the process as well as how it proceeds with substantial conformational changes of the polymerase complex determine the mechano-chemical coupling mecha...
Autores principales: | Da, Lin-Tai, E, Chao, Duan, Baogen, Zhang, Chuanbiao, Zhou, Xin, Yu, Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658072/ https://www.ncbi.nlm.nih.gov/pubmed/26599007 http://dx.doi.org/10.1371/journal.pcbi.1004624 |
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