Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

A hallmark of Alzheimer’s disease (AD) is the accumulation of extracellular amyloid-β (Aβ) plaques in the brains of patients. N-terminally truncated pyroglutamate-modified Aβ (pEAβ) has been described as a major compound of Aβ species in senile plaques. pEAβ is more resistant to degradation, shows h...

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Detalles Bibliográficos
Autores principales: Dammers, Christina, Gremer, Lothar, Reiß, Kerstin, Klein, Antonia N., Neudecker, Philipp, Hartmann, Rudolf, Sun, Na, Demuth, Hans-Ulrich, Schwarten, Melanie, Willbold, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658145/
https://www.ncbi.nlm.nih.gov/pubmed/26600248
http://dx.doi.org/10.1371/journal.pone.0143647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658145/
https://www.ncbi.nlm.nih.gov/pubmed/26600248
http://dx.doi.org/10.1371/journal.pone.0143647

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