Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation

Linear ubiquitination is an atypical posttranslational modification catalyzed by the linear-ubiquitin-chain assembly complex (LUBAC), containing HOIP, HOIL-1L, and Sharpin. LUBAC facilitates NF-κB activation and inflammation upon receptor stimulation by ligating linear ubiquitin chains to critical s...

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Detalles Bibliográficos
Autores principales: Bowman, James, Rodgers, Mary A., Shi, Mude, Amatya, Rina, Hostager, Bruce, Iwai, Kazuhiro, Gao, Shou-Jiang, Jung, Jae U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659476/
https://www.ncbi.nlm.nih.gov/pubmed/26578682
http://dx.doi.org/10.1128/mBio.01777-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659476/
https://www.ncbi.nlm.nih.gov/pubmed/26578682
http://dx.doi.org/10.1128/mBio.01777-15

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