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Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation
Linear ubiquitination is an atypical posttranslational modification catalyzed by the linear-ubiquitin-chain assembly complex (LUBAC), containing HOIP, HOIL-1L, and Sharpin. LUBAC facilitates NF-κB activation and inflammation upon receptor stimulation by ligating linear ubiquitin chains to critical s...
Autores principales: | Bowman, James, Rodgers, Mary A., Shi, Mude, Amatya, Rina, Hostager, Bruce, Iwai, Kazuhiro, Gao, Shou-Jiang, Jung, Jae U. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Microbiology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659476/ https://www.ncbi.nlm.nih.gov/pubmed/26578682 http://dx.doi.org/10.1128/mBio.01777-15 |
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