DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

Extensive damage to maternal DNA during meiosis causes infertility, birth defects and abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the creation of DNA-damaged embryos. Here we show that DNA damage activates a pathway involving the spindle assembly checkpoint (...

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Detalles Bibliográficos
Autores principales: Collins, Josie K., Lane, Simon I. R., Merriman, Julie A., Jones, Keith T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659839/
https://www.ncbi.nlm.nih.gov/pubmed/26522232
http://dx.doi.org/10.1038/ncomms9553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659839/
https://www.ncbi.nlm.nih.gov/pubmed/26522232
http://dx.doi.org/10.1038/ncomms9553

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