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KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing

In the cochlea, K(+) is essential for mechano-electrical transduction. Here, we explore cochlear structure and function in mice lacking K(+) channels of the two-pore domain family. A profound deafness associated with a decrease in endocochlear potential is found in adult Kcnk5(−/−) mice. Hearing occ...

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Detalles Bibliográficos
Autores principales: Cazals, Yves, Bévengut, Michelle, Zanella, Sébastien, Brocard, Frédéric, Barhanin, Jacques, Gestreau, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659937/
https://www.ncbi.nlm.nih.gov/pubmed/26549439
http://dx.doi.org/10.1038/ncomms9780