Cargando…
KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing
In the cochlea, K(+) is essential for mechano-electrical transduction. Here, we explore cochlear structure and function in mice lacking K(+) channels of the two-pore domain family. A profound deafness associated with a decrease in endocochlear potential is found in adult Kcnk5(−/−) mice. Hearing occ...
Autores principales: | Cazals, Yves, Bévengut, Michelle, Zanella, Sébastien, Brocard, Frédéric, Barhanin, Jacques, Gestreau, Christian |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659937/ https://www.ncbi.nlm.nih.gov/pubmed/26549439 http://dx.doi.org/10.1038/ncomms9780 |
Ejemplares similares
-
Low‐dose rapamycin‐induced autophagy in cochlear outer sulcus cells
por: Saegusa, Chika, et al.
Publicado: (2020) -
2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2)
por: Beltrán, Leopoldo, et al.
Publicado: (2013) -
Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b
por: Nasr, Nathalie, et al.
Publicado: (2018) -
PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice
por: Li, Jie, et al.
Publicado: (2021) -
Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the Basal Cochlear Region
por: Szepesy, Judit, et al.
Publicado: (2020)