Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

The age-dependent deposition of amyloid-β peptides, derived from amyloid precursor protein (APP), is a neuropathological hallmark of Alzheimer's disease (AD). Despite age being the greatest risk factor for AD, the molecular mechanisms linking ageing to APP processing are unknown. Here we show t...

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Detalles Bibliográficos
Autores principales: Zhang, Zhentao, Song, Mingke, Liu, Xia, Su Kang, Seong, Duong, Duc M., Seyfried, Nicholas T., Cao, Xuebing, Cheng, Liming, Sun, Yi E., Ping Yu, Shan, Jia, Jianping, Levey, Allan I., Ye, Keqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659940/
https://www.ncbi.nlm.nih.gov/pubmed/26549211
http://dx.doi.org/10.1038/ncomms9762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659940/
https://www.ncbi.nlm.nih.gov/pubmed/26549211
http://dx.doi.org/10.1038/ncomms9762

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