Asparagine requirement in Plasmodium berghei as a target to prevent malaria transmission and liver infections

The proteins of Plasmodium, the malaria parasite, are strikingly rich in asparagine. Plasmodium depends primarily on host haemoglobin degradation for amino acids and has a rudimentary pathway for amino acid biosynthesis, but retains a gene encoding asparagine synthetase (AS). Here we show that delet...

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Detalles Bibliográficos
Autores principales: Nagaraj, Viswanathan A., Mukhi, Dhanunjay, Sathishkumar, Vinayagam, Subramani, Pradeep A., Ghosh, Susanta K., Pandey, Rajeev R., Shetty, Manjunatha C., Padmanaban, Govindarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659947/
https://www.ncbi.nlm.nih.gov/pubmed/26531182
http://dx.doi.org/10.1038/ncomms9775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659947/
https://www.ncbi.nlm.nih.gov/pubmed/26531182
http://dx.doi.org/10.1038/ncomms9775

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