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Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM
A current challenge in life sciences is to image cell membrane receptors while characterizing their specific interactions with various ligands. Addressing this issue has been hampered by the lack of suitable nanoscopic methods. Here we address this challenge and introduce multifunctional high-resolu...
Autores principales: | Pfreundschuh, Moritz, Alsteens, David, Wieneke, Ralph, Zhang, Cheng, Coughlin, Shaun R., Tampé, Robert, Kobilka, Brian K., Müller, Daniel J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660198/ https://www.ncbi.nlm.nih.gov/pubmed/26561004 http://dx.doi.org/10.1038/ncomms9857 |
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