Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice

Sperm–egg fusion is indispensable for completing mammalian fertilization. Although the underlying molecular mechanisms are poorly understood, requirement of two spermatozoon factors, IZUMO1 and SPACA6, and two oocyte factors, CD9 and the IZUMO1 counter-receptor JUNO, has been proven by gene disrupti...

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Detalles Bibliográficos
Autores principales: Inoue, Naokazu, Hagihara, Yoshihisa, Wright, Danelle, Suzuki, Takahisa, Wada, Ikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660202/
https://www.ncbi.nlm.nih.gov/pubmed/26568141
http://dx.doi.org/10.1038/ncomms9858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660202/
https://www.ncbi.nlm.nih.gov/pubmed/26568141
http://dx.doi.org/10.1038/ncomms9858

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