Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers

Aggregation of highly phosphorylated tau is a hallmark of Alzheimer’s disease and other tauopathies. Nevertheless, animal models demonstrate that tau-mediated dysfunction/toxicity may not require large tau aggregates but instead may be caused by soluble hyper-phosphorylated tau or by small tau oligo...

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Detalles Bibliográficos
Autores principales: Cowan, Catherine M., Quraishe, Shmma, Hands, Sarah, Sealey, Megan, Mahajan, Sumeet, Allan, Douglas W., Mudher, Amritpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660438/
https://www.ncbi.nlm.nih.gov/pubmed/26608845
http://dx.doi.org/10.1038/srep17191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660438/
https://www.ncbi.nlm.nih.gov/pubmed/26608845
http://dx.doi.org/10.1038/srep17191

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