Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5’-diphospho-glucuronosyltransferase isoforms

BACKGROUND: Glucuronidation catalyzed by uridine 5’- diphospho-glucuronosyltransferase (UGT) is a major phase II drug metabolism reaction which facilitates drug elimination. Inhibition of UGT activity can cause drug-drug interaction. Therefore, it is important to determine the inhibitory potentials...

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Detalles Bibliográficos
Autores principales: Haron, Munirah, Ismail, Sabariah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660513/
https://www.ncbi.nlm.nih.gov/pubmed/26692748
http://dx.doi.org/10.4103/0974-8490.159580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660513/
https://www.ncbi.nlm.nih.gov/pubmed/26692748
http://dx.doi.org/10.4103/0974-8490.159580

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