Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale

Two strategies for the synthesis of the ATP (adenosine triphosphate) analogue ApppI [1-adenosin-5’-yl 3-(3-methylbut-3-enyl)triphosphoric acid diester] (1) are described. ApppI is an active metabolite of the mevalonate pathway and thus is of major biological significance. Chemically synthezised Appp...

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Autores principales: Weisell, Janne, Vepsäläinen, Jouko, Turhanen, Petri A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660979/
https://www.ncbi.nlm.nih.gov/pubmed/26664641
http://dx.doi.org/10.3762/bjoc.11.237
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author Weisell, Janne
Vepsäläinen, Jouko
Turhanen, Petri A
author_facet Weisell, Janne
Vepsäläinen, Jouko
Turhanen, Petri A
author_sort Weisell, Janne
collection PubMed
description Two strategies for the synthesis of the ATP (adenosine triphosphate) analogue ApppI [1-adenosin-5’-yl 3-(3-methylbut-3-enyl)triphosphoric acid diester] (1) are described. ApppI is an active metabolite of the mevalonate pathway and thus is of major biological significance. Chemically synthezised ApppI was purified by using triethylammonium bicarbonate as the counter ion in ion-pair chromatography and characterized by (1)H, (13)C, (31)P NMR and MS spectroscopical methods.
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spelling pubmed-46609792015-12-09 Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale Weisell, Janne Vepsäläinen, Jouko Turhanen, Petri A Beilstein J Org Chem Letter Two strategies for the synthesis of the ATP (adenosine triphosphate) analogue ApppI [1-adenosin-5’-yl 3-(3-methylbut-3-enyl)triphosphoric acid diester] (1) are described. ApppI is an active metabolite of the mevalonate pathway and thus is of major biological significance. Chemically synthezised ApppI was purified by using triethylammonium bicarbonate as the counter ion in ion-pair chromatography and characterized by (1)H, (13)C, (31)P NMR and MS spectroscopical methods. Beilstein-Institut 2015-11-13 /pmc/articles/PMC4660979/ /pubmed/26664641 http://dx.doi.org/10.3762/bjoc.11.237 Text en Copyright © 2015, Weisell et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Weisell, Janne
Vepsäläinen, Jouko
Turhanen, Petri A
Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale
title Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale
title_full Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale
title_fullStr Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale
title_full_unstemmed Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale
title_short Two strategies for the synthesis of the biologically important ATP analogue ApppI, at a multi-milligram scale
title_sort two strategies for the synthesis of the biologically important atp analogue apppi, at a multi-milligram scale
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660979/
https://www.ncbi.nlm.nih.gov/pubmed/26664641
http://dx.doi.org/10.3762/bjoc.11.237
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AT turhanenpetria twostrategiesforthesynthesisofthebiologicallyimportantatpanalogueapppiatamultimilligramscale

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