Rhesus macaque θ‐defensin RTD‐1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF‐κB and MAPK pathways

θ‐Defensins are pleiotropic, macrocyclic peptides that are expressed uniquely in Old World monkeys. The peptides are potent, broad‐spectrum microbicides that also modulate inflammatory responses in vitro and in animal models of viral infection and polymicrobial sepsis. θ‐Defensins suppress proinflam...

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Detalles Bibliográficos
Autores principales: Tongaonkar, Prasad, Trinh, Katie K., Schaal, Justin B., Tran, Dat, Gulko, Percio S., Ouellette, André J., Selsted, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Inflammation, Extracellular Mediators, & Effector Molecules
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661038/
https://www.ncbi.nlm.nih.gov/pubmed/26269197
http://dx.doi.org/10.1189/jlb.3A0315-102R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661038/
https://www.ncbi.nlm.nih.gov/pubmed/26269197
http://dx.doi.org/10.1189/jlb.3A0315-102R

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