G9a Is Essential for Epigenetic Silencing of K(+) Channel Genes in Acute-to-Chronic Pain Transition

Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a long-lasting reduction in K(+) channel expression in the dorsal root ganglion (DRG), but little is known about the epigenetic mechanisms involved. Here we show that nerve injury increased H3K9me2 occupa...

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Detalles Bibliográficos
Autores principales: Laumet, Geoffroy, Garriga, Judit, Chen, Shao-Rui, Zhang, Yuhao, Li, De-Pei, Smith, Trevor M., Dong, Yingchun, Jelinek, Jaroslav, Cesaroni, Matteo, Issa, Jean-Pierre, Pan, Hui-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661086/
https://www.ncbi.nlm.nih.gov/pubmed/26551542
http://dx.doi.org/10.1038/nn.4165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661086/
https://www.ncbi.nlm.nih.gov/pubmed/26551542
http://dx.doi.org/10.1038/nn.4165

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