Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults
Carnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed to investigate their cognitive and neurophysiological effects, using functional MRI, on humans. Thirty-one healthy participants (age 40–78, 10 male/21 female) were recruite...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661275/ https://www.ncbi.nlm.nih.gov/pubmed/26640437 http://dx.doi.org/10.3389/fnagi.2015.00219 |
_version_ | 1782402954690560000 |
---|---|
author | Rokicki, Jaroslav Li, Lucia Imabayashi, Etsuko Kaneko, Jun Hisatsune, Tatsuhiro Matsuda, Hiroshi |
author_facet | Rokicki, Jaroslav Li, Lucia Imabayashi, Etsuko Kaneko, Jun Hisatsune, Tatsuhiro Matsuda, Hiroshi |
author_sort | Rokicki, Jaroslav |
collection | PubMed |
description | Carnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed to investigate their cognitive and neurophysiological effects, using functional MRI, on humans. Thirty-one healthy participants (age 40–78, 10 male/21 female) were recruited to a double-blind placebo-controlled study. Participants were assigned to twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo (n = 17). Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation. We analyzed resting state functional connectivity with the FSL fMRI analysis package. There were no differences in neuropsychological scores between the groups at baseline. After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the default mode network, the posterior cingulate cortex and the right fronto parietal network, as compared with the placebo group. Furthermore, there was a correlation between the extents of cognitive and neuroimaging changes. These results suggest that daily carnosine/anserine supplementation can impact cognitive function and that network connectivity changes are associated with its effects. |
format | Online Article Text |
id | pubmed-4661275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46612752015-12-04 Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults Rokicki, Jaroslav Li, Lucia Imabayashi, Etsuko Kaneko, Jun Hisatsune, Tatsuhiro Matsuda, Hiroshi Front Aging Neurosci Neuroscience Carnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed to investigate their cognitive and neurophysiological effects, using functional MRI, on humans. Thirty-one healthy participants (age 40–78, 10 male/21 female) were recruited to a double-blind placebo-controlled study. Participants were assigned to twice-daily doses of imidazole dipeptide formula (n = 14), containing 500 mg (carnosine/anserine, ratio 1/3) or an identical placebo (n = 17). Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation. We analyzed resting state functional connectivity with the FSL fMRI analysis package. There were no differences in neuropsychological scores between the groups at baseline. After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the default mode network, the posterior cingulate cortex and the right fronto parietal network, as compared with the placebo group. Furthermore, there was a correlation between the extents of cognitive and neuroimaging changes. These results suggest that daily carnosine/anserine supplementation can impact cognitive function and that network connectivity changes are associated with its effects. Frontiers Media S.A. 2015-11-27 /pmc/articles/PMC4661275/ /pubmed/26640437 http://dx.doi.org/10.3389/fnagi.2015.00219 Text en Copyright © 2015 Rokicki, Li, Imabayashi, Kaneko, Hisatsune and Matsuda. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Rokicki, Jaroslav Li, Lucia Imabayashi, Etsuko Kaneko, Jun Hisatsune, Tatsuhiro Matsuda, Hiroshi Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults |
title | Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults |
title_full | Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults |
title_fullStr | Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults |
title_full_unstemmed | Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults |
title_short | Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults |
title_sort | daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661275/ https://www.ncbi.nlm.nih.gov/pubmed/26640437 http://dx.doi.org/10.3389/fnagi.2015.00219 |
work_keys_str_mv | AT rokickijaroslav dailycarnosineandanserinesupplementationaltersverbalepisodicmemoryandrestingstatenetworkconnectivityinhealthyelderlyadults AT lilucia dailycarnosineandanserinesupplementationaltersverbalepisodicmemoryandrestingstatenetworkconnectivityinhealthyelderlyadults AT imabayashietsuko dailycarnosineandanserinesupplementationaltersverbalepisodicmemoryandrestingstatenetworkconnectivityinhealthyelderlyadults AT kanekojun dailycarnosineandanserinesupplementationaltersverbalepisodicmemoryandrestingstatenetworkconnectivityinhealthyelderlyadults AT hisatsunetatsuhiro dailycarnosineandanserinesupplementationaltersverbalepisodicmemoryandrestingstatenetworkconnectivityinhealthyelderlyadults AT matsudahiroshi dailycarnosineandanserinesupplementationaltersverbalepisodicmemoryandrestingstatenetworkconnectivityinhealthyelderlyadults |