Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks

Indoleamine 2,3 -dioxygenase 1 (IDO1) catalyzes L-tryptophan to kynurenine in the first and rate-limiting step of tryptophan metabolism. IDO1 is expressed widely throughout the body, with especially high expression in colonic intestinal tissues. To examine the role of IDO1 in the colon, transcriptom...

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Detalles Bibliográficos
Autores principales: Shon, Woo-Jeong, Lee, Young-Kwan, Shin, Ji Hee, Choi, Eun Young, Shin, Dong-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661522/
https://www.ncbi.nlm.nih.gov/pubmed/26610689
http://dx.doi.org/10.1038/srep17305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661522/
https://www.ncbi.nlm.nih.gov/pubmed/26610689
http://dx.doi.org/10.1038/srep17305

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