Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate

Methotrexate has been in use as an anti-cancer agent for over 60 years. Though inhibition of dihydrofolate reductase is its best known mechanisms of action, its non-dihydrofolate reductase dependent mechanisms disrupt metabolic pathways resulting in a depletion of NAD(P)H and increasing oxidative st...

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Detalles Bibliográficos
Autores principales: Hess, Joshua A., Khasawneh, Mohamad K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661551/
https://www.ncbi.nlm.nih.gov/pubmed/26674389
http://dx.doi.org/10.1016/j.bbacli.2015.01.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661551/
https://www.ncbi.nlm.nih.gov/pubmed/26674389
http://dx.doi.org/10.1016/j.bbacli.2015.01.006

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