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Truncated HSPB1 causes axonal neuropathy and impairs tolerance to unfolded protein stress
BACKGROUND: HSPB1 belongs to the family of small heat shock proteins (sHSP) that have importance in protection against unfolded protein stress, in cancer cells for escaping drug toxicity stress and in neurons for suppression of protein aggregates. sHSPs have a conserved α-crystalline domain (ACD), f...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661565/ https://www.ncbi.nlm.nih.gov/pubmed/26675522 http://dx.doi.org/10.1016/j.bbacli.2015.03.002 |