ω-Tbo-IT1–New Inhibitor of Insect Calcium Channels Isolated from Spider Venom

Novel disulfide-containing polypeptide toxin was discovered in the venom of the Tibellus oblongus spider. We report on isolation, spatial structure determination and electrophysiological characterization of this 41-residue toxin, called ω-Tbo-IT1. It has an insect-toxic effect with LD(50) 19 μg/g in...

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Detalles Bibliográficos
Autores principales: Mikov, Alexander N., Fedorova, Irina M., Potapieva, Natalia N., Maleeva, Ekaterina E., Andreev, Yaroslav A., Zaitsev, Alexey V., Kim, Kira K., Bocharov, Eduard V., Bozin, Timur N., Altukhov, Dmitry A., Lipkin, Alexey V., Kozlov, Sergey A., Tikhonov, Denis B., Grishin, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661699/
https://www.ncbi.nlm.nih.gov/pubmed/26611444
http://dx.doi.org/10.1038/srep17232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661699/
https://www.ncbi.nlm.nih.gov/pubmed/26611444
http://dx.doi.org/10.1038/srep17232

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