Alteration of the Donor/Acceptor Spectrum of the (S)-Amine Transaminase from Vibrio fluvialis

To alter the amine donor/acceptor spectrum of an (S)-selective amine transaminase (ATA), a library based on the Vibrio fluvialis ATA targeting four residues close to the active site (L56, W57, R415 and L417) was created. A 3DM-derived alignment comprising fold class I pyridoxal-5′-phosphate (PLP)-de...

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Detalles Bibliográficos
Autores principales: Genz, Maika, Vickers, Clare, van den Bergh, Tom, Joosten, Henk-Jan, Dörr, Mark, Höhne, Matthias, Bornscheuer, Uwe T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661865/
https://www.ncbi.nlm.nih.gov/pubmed/26569229
http://dx.doi.org/10.3390/ijms161126007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661865/
https://www.ncbi.nlm.nih.gov/pubmed/26569229
http://dx.doi.org/10.3390/ijms161126007

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