Cargando…

Sildenafil Protects against Myocardial Ischemia-Reperfusion Injury Following Cardiac Arrest in a Porcine Model: Possible Role of the Renin-Angiotensin System

Sildenafil, a phosphodiesterase-5 inhibitor sold as Viagra, is a cardioprotector against myocardial ischemia/reperfusion (I/R) injury. Our study explored whether sildenafil protects against I/R-induced damage in a porcine cardiac arrest and resuscitation (CAR) model via modulating the renin-angioten...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Guoxing, Zhang, Qian, Yuan, Wei, Wu, Junyuan, Li, Chunsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661868/ https://www.ncbi.nlm.nih.gov/pubmed/26569234 http://dx.doi.org/10.3390/ijms161126010

Ejemplares similares

Enalapril protects against myocardial ischemia/reperfusion injury in a swine model of cardiac arrest and resuscitation
por: Wang, Guoxing, et al.
Publicado: (2016)

The protective effects of a phosphodiesterase 5 inhibitor, sildenafil, on postresuscitation cardiac dysfunction of cardiac arrest: metabolic evidence from microdialysis
por: Zhang, Qian, et al.
Publicado: (2014)

Role of cardiac renin angiotensin system in ischemia reperfusion injury and preconditioning of heart
por: Agrawal, Vimal, et al.
Publicado: (2016)

Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension
por: Husková, Zuzana, et al.
Publicado: (2023)

The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: essential role of nitric oxide syntheses signaling
por: Zhang, Qian, et al.
Publicado: (2015)

Renin Angiotensin System as a Regulator of Cell Volume. Implications to Myocardial Ischemia
por: De Mello, Walmor C
Publicado: (2009)

The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion
por: Rodríguez-Lara, Simón Quetzalcóatl, et al.
Publicado: (2018)

Interaction of Sex Hormones and the Renin–Angiotensin System in Ovariectomized Rats Subjected to Ischemia-Reperfusion Induction
por: Lakzaei, Halimeh, et al.
Publicado: (2019)

View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury
por: Karimi, Farzaneh, et al.
Publicado: (2022)

Erythropoietin and sildenafil protect against ischemia/reperfusion injury following testicular torsion in adult rats
por: Kostakis, Ioannis D., et al.
Publicado: (2017)

Combination of Epinephrine with Esmolol Attenuates Post-Resuscitation Myocardial Dysfunction in a Porcine Model of Cardiac Arrest
por: Zhang, Qian, et al.
Publicado: (2013)

The protective effects of phosphodiesterase-5 inhibitor, sildenafil on post-resuscitation cardiac dysfunction of cardiac arrest: by regulating the miR-155-5p and miR-145-5p
por: He, Yong, et al.
Publicado: (2021)

Serum Metabolomics Reveals Distinct Profiles during Ischemia and Reperfusion in a Porcine Model of Myocardial Ischemia–Reperfusion
por: Goetzman, Eric, et al.
Publicado: (2022)

The Role of Vasodilator Receptors of Renin–angiotensin System on Nitric Oxide Formation and Kidney Circulation after Angiotensin II Infusion in Renal Ischemia/Reperfusion Rats
por: Maleki, Maryam, et al.
Publicado: (2018)

The Interplay between the Renin Angiotensin System and Pacing Postconditioning Induced Cardiac Protection
por: Babiker, Fawzi, et al.
Publicado: (2016)

Protective role of silibinin against myocardial ischemia/reperfusion injury-induced cardiac dysfunction
por: Chen, Yi-He, et al.
Publicado: (2020)

Communication Between Cardiomyocytes and Fibroblasts During Cardiac Ischemia/Reperfusion and Remodeling: Roles of TGF-β, CTGF, the Renin Angiotensin Axis, and Non-coding RNA Molecules
por: Flores-Vergara, Raúl, et al.
Publicado: (2021)

Sildenafil-mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: role of VEGF/angiopoietin-1
por: Koneru, Srikanth, et al.
Publicado: (2008)

Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury
por: Qian, Weidong, et al.
Publicado: (2014)

Protective approaches against myocardial ischemia reperfusion injury
por: Li, Xianchi, et al.
Publicado: (2016)

Protective effect of celastrol on myocardial ischemia–reperfusion injury
por: Li, Xiaoyan, et al.
Publicado: (2017)

Protective role of fibrates in cardiac ischemia/reperfusion
por: Singh, G., et al.
Publicado: (2012)

Hyperoxia after cardiac arrest may not increase ischemia-reperfusion injury
por: Hoedemaekers, Cornelia W, et al.
Publicado: (2011)

The renin–angiotensin system: a possible new target for depression
por: Vian, João, et al.
Publicado: (2017)

Extracorporeal membrane oxygenation mitigates myocardial injury and improves survival in porcine model of ventricular fibrillation cardiac arrest
por: Liu, Bo, et al.
Publicado: (2019)

Direct Renin Inhibition With Aliskiren Protects Against Myocardial Ischemia/Reperfusion Injury by Activating Nitric Oxide Synthase Signaling in Spontaneously Hypertensive Rats
por: Zhang, Wen, et al.
Publicado: (2014)

Cardiac Microvascular Barrier Function Mediates the Protection of Tongxinluo against Myocardial Ischemia/Reperfusion Injury
por: Qi, Kang, et al.
Publicado: (2015)

Protective Effect of Shen-Fu Injection on Neuronal Mitochondrial Function in a Porcine Model of Prolonged Cardiac Arrest
por: Gu, Wei, et al.
Publicado: (2014)

Increased Endogenous Activity of the Renin-Angiotensin System Reduces Infarct Size in the Rats with Early Angiotensin II-dependent Hypertension which Survive the Acute Ischemia/Reperfusion Injury
por: Husková, Zuzana, et al.
Publicado: (2021)

Sildenafil Attenuates Hepatocellular Injury after Liver Ischemia Reperfusion in Rats: A Preliminary Study
por: Savvanis, Spyridon, et al.
Publicado: (2014)

Protective effects of GV1001 on myocardial ischemia-reperfusion injury
por: Chang, Ji-Eun, et al.
Publicado: (2017)

Protective effect of morin on myocardial ischemia-reperfusion injury in rats
por: Liu, Shuang, et al.
Publicado: (2018)

Protective Mechanisms of Quercetin Against Myocardial Ischemia Reperfusion Injury
por: Zhang, Yu-Min, et al.
Publicado: (2020)

Protective effects of fisetin against myocardial ischemia/reperfusion injury
por: Long, Lihui, et al.
Publicado: (2020)

Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury
por: Hałucha, Kornela, et al.
Publicado: (2021)

Saponins in Chinese Herbal Medicine Exerts Protection in Myocardial Ischemia–Reperfusion Injury: Possible Mechanism and Target Analysis
por: Wang, Ruiying, et al.
Publicado: (2021)

Imbalance of angiotensin-converting enzymes affects myocardial apoptosis during cardiac arrest induced by acute pulmonary embolism in a porcine model
por: Xiao, Hong-Li, et al.
Publicado: (2019)

A Long-Term and Slow-Releasing Hydrogen Sulfide Donor Protects against Myocardial Ischemia/Reperfusion Injury
por: Sun, Xiaotian, et al.
Publicado: (2017)

Renin–Angiotensin System Antagonism Protects the Diabetic Heart from Ischemia/Reperfusion Injury in Variable Hyperglycemia Duration Settings by a Glucose Transporter Type 4-Mediated Pathway
por: Al-Kouh, Aisha, et al.
Publicado: (2023)

What’s new in the renin-angiotensin system?: What’s new in the renin-angiotensin system?
por: Smith, A. I., et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_59ef5a6n93b014eu0d63h7oabo