Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells

Ovarian carcinoma (OC) is one of the most common gynecological malignancies, with a poor prognosis for patients at advanced stage. Danusertib (Danu) is a pan-inhibitor of the Aurora kinases with unclear anticancer effect and underlying mechanisms in OC treatment. This study aimed to examine the canc...

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Detalles Bibliográficos
Autores principales: Zi, Dan, Zhou, Zhi-Wei, Yang, Ying-Jie, Huang, Lin, Zhou, Zun-Lun, He, Shu-Ming, He, Zhi-Xu, Zhou, Shu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661876/
https://www.ncbi.nlm.nih.gov/pubmed/26580601
http://dx.doi.org/10.3390/ijms161126018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661876/
https://www.ncbi.nlm.nih.gov/pubmed/26580601
http://dx.doi.org/10.3390/ijms161126018

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