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Nucleotide-Induced Conformational Changes in Escherichia coli DnaA Protein Are Required for Bacterial ORC to Pre-RC Conversion at the Chromosomal Origin
DnaA oligomerizes when bound to origins of chromosomal replication. Structural analysis of a truncated form of DnaA from Aquifex aeolicus has provided insight into crucial conformational differences within the AAA+ domain that are specific to the ATP- versus ADP- bound form of DnaA. In this study mo...
Autores principales: | Saxena, Rahul, Vasudevan, Sona, Patil, Digvijay, Ashoura, Norah, Grimwade, Julia E., Crooke, Elliott |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661922/ https://www.ncbi.nlm.nih.gov/pubmed/26610483 http://dx.doi.org/10.3390/ijms161126064 |
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