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Tuneable endogenous mammalian target complementation via multiplexed plasmid-based recombineering
Understanding the quantitative functional consequences of human disease mutations requires silencing of endogenous genes and expression of mutants at close to physiological levels. Changing protein levels above or below these levels is also important for system perturbation and modelling. Fast desig...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661934/ https://www.ncbi.nlm.nih.gov/pubmed/26612112 http://dx.doi.org/10.1038/srep17432 |