The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism

Manipulation of metabolic pathways in hematological cancers has therapeutic potential. Here, we determined the molecular mechanism of action of the metabolic modulator dichloroacetate (DCA) in leukemic cells. We found that DCA induces the AMP-activated protein kinase (AMPK)/p53 pathway with increase...

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Detalles Bibliográficos
Autores principales: Allende-Vega, Nerea, Krzywinska, Ewelina, Orecchioni, Stefania, Lopez-Royuela, Nuria, Reggiani, Francesca, Talarico, Giovanna, Rossi, Jean-François, Rossignol, Rodrigue, Hicheri, Yosr, Cartron, Guillaume, Bertolini, Francesco, Villalba, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662487/
https://www.ncbi.nlm.nih.gov/pubmed/26231043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662487/
https://www.ncbi.nlm.nih.gov/pubmed/26231043

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