Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

Cancer‐associated fibroblasts (CAFs) interact with tumour cells and promote growth and metastasis. Here, we show that CAF activation is reversible: chronic hypoxia deactivates CAFs, resulting in the loss of contractile force, reduced remodelling of the surrounding extracellular matrix and, ultimatel...

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Detalles Bibliográficos
Autores principales: Madsen, Chris D, Pedersen, Jesper T, Venning, Freja A, Singh, Lukram Babloo, Moeendarbary, Emad, Charras, Guillaume, Cox, Thomas R, Sahai, Erik, Erler, Janine T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662858/
https://www.ncbi.nlm.nih.gov/pubmed/26323721
http://dx.doi.org/10.15252/embr.201540107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662858/
https://www.ncbi.nlm.nih.gov/pubmed/26323721
http://dx.doi.org/10.15252/embr.201540107

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