Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population

To investigate the association of MET SNPs with gender disparity in thyroid tumors, as well as the metastasis and prognosis of patients, 858 patients with papillary thyroid carcinoma (PTC), 556 patients with nodular goiter, and 896 population-based normal controls were recruited. The genotyping of M...

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Autores principales: Ning, Lifeng, Yu, Yaqin, Liu, Xiaoli, Ai, Lizhe, Zhang, Xin, Rao, Wenwang, Shi, Jieping, Sun, Hui, Yu, Qiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662967/
https://www.ncbi.nlm.nih.gov/pubmed/26649038
http://dx.doi.org/10.1155/2015/405217
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author Ning, Lifeng
Yu, Yaqin
Liu, Xiaoli
Ai, Lizhe
Zhang, Xin
Rao, Wenwang
Shi, Jieping
Sun, Hui
Yu, Qiong
author_facet Ning, Lifeng
Yu, Yaqin
Liu, Xiaoli
Ai, Lizhe
Zhang, Xin
Rao, Wenwang
Shi, Jieping
Sun, Hui
Yu, Qiong
author_sort Ning, Lifeng
collection PubMed
description To investigate the association of MET SNPs with gender disparity in thyroid tumors, as well as the metastasis and prognosis of patients, 858 patients with papillary thyroid carcinoma (PTC), 556 patients with nodular goiter, and 896 population-based normal controls were recruited. The genotyping of MET SNPs was carried out using the Sequenom MassARRAY system. The distribution of MET SNPs (rs1621 and rs6566) was different among groups. Gender stratification analysis revealed a significant association between the rs1621 genotype and PTC in female patients (P = 0.037), but not in male patients (P > 0.05). For female patients, the rs1621 AG genotype was significantly higher in patients with PTC than in normal controls (P = 0.01) and revealed an increasing risk of PTC (OR: 1.465, 95% CI: 1.118–1.92). However, association analysis of the rs1621 genotype with metastasis and prognosis revealed no significant correlation in both male and female patients. The findings of our study showed that polymorphism of SNP locus rs1621 in MET gene may be associated with gender disparity in PTC. Higher AG genotypes in rs1621 were correlated with PTC in female patients, but not in male patients.
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spelling pubmed-46629672015-12-08 Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population Ning, Lifeng Yu, Yaqin Liu, Xiaoli Ai, Lizhe Zhang, Xin Rao, Wenwang Shi, Jieping Sun, Hui Yu, Qiong Int J Endocrinol Research Article To investigate the association of MET SNPs with gender disparity in thyroid tumors, as well as the metastasis and prognosis of patients, 858 patients with papillary thyroid carcinoma (PTC), 556 patients with nodular goiter, and 896 population-based normal controls were recruited. The genotyping of MET SNPs was carried out using the Sequenom MassARRAY system. The distribution of MET SNPs (rs1621 and rs6566) was different among groups. Gender stratification analysis revealed a significant association between the rs1621 genotype and PTC in female patients (P = 0.037), but not in male patients (P > 0.05). For female patients, the rs1621 AG genotype was significantly higher in patients with PTC than in normal controls (P = 0.01) and revealed an increasing risk of PTC (OR: 1.465, 95% CI: 1.118–1.92). However, association analysis of the rs1621 genotype with metastasis and prognosis revealed no significant correlation in both male and female patients. The findings of our study showed that polymorphism of SNP locus rs1621 in MET gene may be associated with gender disparity in PTC. Higher AG genotypes in rs1621 were correlated with PTC in female patients, but not in male patients. Hindawi Publishing Corporation 2015 2015-11-15 /pmc/articles/PMC4662967/ /pubmed/26649038 http://dx.doi.org/10.1155/2015/405217 Text en Copyright © 2015 Lifeng Ning et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ning, Lifeng
Yu, Yaqin
Liu, Xiaoli
Ai, Lizhe
Zhang, Xin
Rao, Wenwang
Shi, Jieping
Sun, Hui
Yu, Qiong
Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population
title Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population
title_full Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population
title_fullStr Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population
title_full_unstemmed Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population
title_short Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population
title_sort association analysis of met gene polymorphism with papillary thyroid carcinoma in a chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662967/
https://www.ncbi.nlm.nih.gov/pubmed/26649038
http://dx.doi.org/10.1155/2015/405217
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