PFOS Disturbs BDNF-ERK-CREB Signalling in Association with Increased MicroRNA-22 in SH-SY5Y Cells

Perfluorooctane sulfonate (PFOS), a ubiquitous environmental pollutant, is neurotoxic to mammalian species. However, the underlying mechanism of its neurotoxicity was unclear. We hypothesized that PFOS suppresses BDNF expression to produce its neurotoxic effects by inhibiting the ERK-CREB pathway. S...

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Detalles Bibliográficos
Autores principales: Li, Wu, He, Qing-zhi, Wu, Cheng-qiu, Pan, Xiao-yuan, Wang, Jing, Tan, Yan, Shan, Xiao-yun, Zeng, Huai-cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662996/
https://www.ncbi.nlm.nih.gov/pubmed/26649298
http://dx.doi.org/10.1155/2015/302653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662996/
https://www.ncbi.nlm.nih.gov/pubmed/26649298
http://dx.doi.org/10.1155/2015/302653

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