Cargando…
Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane
The mammalian protein vinculin is often a target of bacterial pathogens to subvert locally host cell actin dynamics. In Chlamydia infection, vinculin has been implicated in RNA interference screens, but the molecular basis for vinculin requirement has not been characterized. In this report, we show...
Autores principales: | Thwaites, Tristan R., Pedrosa, Antonio T., Peacock, Thomas P., Carabeo, Rey A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663276/ https://www.ncbi.nlm.nih.gov/pubmed/26649283 http://dx.doi.org/10.3389/fcimb.2015.00088 |
Ejemplares similares
-
Dynamin-dependent entry of Chlamydia trachomatis is sequentially regulated by the effectors TarP and TmeA
por: Romero, Matthew D., et al.
Publicado: (2023) -
A post-invasion role for Chlamydia type III effector TarP in modulating the dynamics and organization of host cell focal adhesions
por: Pedrosa, António T., et al.
Publicado: (2020) -
Chlamydial virulence factor TarP mimics talin to disrupt the talin‐vinculin complex
por: Whitewood, Austin J., et al.
Publicado: (2018) -
The Chlamydia Effector TarP Mimics the Mammalian Leucine-Aspartic Acid Motif of Paxillin to Subvert the Focal Adhesion Kinase during Invasion
por: Thwaites, Tristan, et al.
Publicado: (2014) -
CPn0572, the C. pneumoniae ortholog of TarP, reorganizes the actin cytoskeleton via a newly identified F-actin binding domain and recruitment of vinculin
por: Braun, Corinna, et al.
Publicado: (2019)