Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation

Nupr1 is a chromatin protein, which cooperates with Kras(G12D) to induce PanIN formation and pancreatic cancer development in mice, though the molecular mechanisms underlying this effect remain to be fully characterized. In the current study, we report that Nupr1 acts as a gene modifier of the effec...

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Detalles Bibliográficos
Autores principales: Grasso, Daniel, Bintz, Jennifer, Lomberk, Gwen, Molejon, Maria Ines, Loncle, Celine, Garcia, Maria Noé, Lopez, Maria Belen, Urrutia, Raul, Iovanna, Juan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663475/
https://www.ncbi.nlm.nih.gov/pubmed/26617245
http://dx.doi.org/10.1038/srep17549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663475/
https://www.ncbi.nlm.nih.gov/pubmed/26617245
http://dx.doi.org/10.1038/srep17549

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