Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism

GlgE, an enzyme of the pathway that converts trehalose to α-glucans, is essential for Mycobacterium tuberculosis. Inhibition of GlgE, which transfers maltose from a maltose-1-phosphate donor to α-glucan/maltooligosaccharide chain acceptor, leads to a toxic accumulation of maltose-1-phosphate that cu...

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Detalles Bibliográficos
Autores principales: Mendes, Vitor, Blaszczyk, Michal, Maranha, Ana, Empadinhas, Nuno, Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663749/
https://www.ncbi.nlm.nih.gov/pubmed/26616850
http://dx.doi.org/10.1038/srep17144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663749/
https://www.ncbi.nlm.nih.gov/pubmed/26616850
http://dx.doi.org/10.1038/srep17144

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