Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening

Alkanols are small aliphatic compounds that inhibit voltage-gated K(+) (K(v)) channels through a yet unresolved gating mechanism. K(v) channels detect changes in the membrane potential with their voltage-sensing domains (VSDs) that reorient and generate a transient gating current. Both 1-Butanol (1-...

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Detalles Bibliográficos
Autores principales: Martínez-Morales, Evelyn, Kopljar, Ivan, Snyders, Dirk J., Labro, Alain J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663795/
https://www.ncbi.nlm.nih.gov/pubmed/26616025
http://dx.doi.org/10.1038/srep17402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663795/
https://www.ncbi.nlm.nih.gov/pubmed/26616025
http://dx.doi.org/10.1038/srep17402

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