Oral Delivery of a Novel Recombinant Streptococcus mitis Vector Elicits Robust Vaccine Antigen-Specific Oral Mucosal and Systemic Antibody Responses and T Cell Tolerance

The pioneer human oral commensal bacterium Streptococcus mitis has unique biologic features that make it an attractive mucosal vaccine or therapeutic delivery vector. S. mitis is safe as a natural persistent colonizer of the mouth, throat and nasopharynx and the oral commensal bacterium is capable o...

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Detalles Bibliográficos
Autores principales: Xie, Emily, Kotha, Abhiroop, Biaco, Tracy, Sedani, Nikita, Zou, Jonathan, Stashenko, Phillip, Duncan, Margaret J., Campos-Neto, Antonio, Cayabyab, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664415/
https://www.ncbi.nlm.nih.gov/pubmed/26618634
http://dx.doi.org/10.1371/journal.pone.0143422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664415/
https://www.ncbi.nlm.nih.gov/pubmed/26618634
http://dx.doi.org/10.1371/journal.pone.0143422

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